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Fluorescence microscopy showed, again, the formation of cytoplasmic foci at ≥10 nM ASO concentration, of nuclear foci at ≥25 nM as well as the formation of nuclear filaments at 100 nM (Fig

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One well studied case is that of busulfan (as shown in Scheme 8) [126], an anti-cancer drug now widely employed to suppress lymphocytes and blood cell stem precursors prior to performing life-saving bone marrow transplantation in malignant diseases and in inborn blood diseases [127,128]