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It is linked to increased production of ROS.30,31 Even though ROS is needed at low concentration for sperm capacitation and acrosomal reaction, at high concentrations, it is capable of causing damage in a cascade of reactions involving a wide range of biomolecules.27,32,33,34 Male reproductive organs and gametes are particularly vulnerable to oxidative damage, as testicular tissue and sperm plasma membranes are rich in polyunsaturated fatty acids (PUFA).35,36 When targeting lipids, oxidant compounds can induce a peroxidation chain reaction that produces several toxic lipid aldehyde species including MDA and 4-HNE

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doi: 10.1002/jbt.2570090305