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Click The Image Hypothelamic-Pituitary-Adrenal Axis Chronic stresses, acidosis, pain, hypoglycemia, etc., induce the hypothalamus to release corticotropin releasing hormone (CRH), which acts on the pituitary to cause the release of adrenocorticotropic hormone (ACTH), which acts on the adrenal gland to cause the secretion of cortisol, the major chronic stress hormone
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For more complex matrices, liquid chromatography-mass spectrometry techniques have been developed to detect and measure curcumin traces in food, biological fluids, and other samples (189)