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As summarized in the FY 2022 IPPS/LTCH PPS final rule, many commenters expressed concern with the potential severity level designation changes overall and recommended that CMS delay any possible change to the designation of these codes to give hospitals and their physicians time to prepare

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Inhibiting the activity of system Xc− affects GSH synthesis by inhibiting cystine absorption, leading to decreased GPX activity, reduced cellular antioxidant capacity, accumulation of lipid ROS, and ultimately oxidative damage and ferroptosis