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Methods A PRISMA-guided systematic review (Figure 1) was performed using PubMed and MEDLINE databases, employing search terms “glutathione” AND “topical” AND “skin” OR “dermatology,” yielding 446 articles with no time restriction

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In any case, the here reported beneficial effects of FOXO4-DRI provide a wide range of possibilities for studying the potential of therapeutic removal of senescence against diseases for which few options are available