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Triple agonists: retatrutide adds glucagon receptor activity, which may increase energy expenditure and hepatic fat oxidation
AHK-Cu peptide
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NICE-recommended weight management strategies include: Dietary intervention – aiming for a 600 kcal/day deficit through reduced portion sizes, limiting energy-dense foods, and increasing fruit and vegetable consumption Physical activity – building up to 150–300 minutes of moderate-intensity aerobic activity weekly, plus muscle-strengthening activities on at least two days weekly, in line with UK Chief Medical Officers' guidelines [10] Behavioural approaches – including self-monitoring, goal-setting, and addressing emotional eating patterns Commercial weight management programmes – such as those meeting NICE quality standards (QS127) Very-low-calorie diets – in specific circumstances, under clinical supervision and for limited periods For patients with a BMI ≥30 kg/m² (or ≥27.5 kg/m² in those of South Asian, Chinese, or other Asian family origin) who have not achieved adequate weight loss through lifestyle measures alone, pharmacological interventions may be considered
