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Moreover, the number of senescent cells also increase with culture time, resulting in a loss of division capabilities, resistance to apoptosis, and the acquisition of a robust proinflammatory secretome known as the senescence-associated secretory phenotype (SASP) (Jeon et al., 2018)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 94.Wang H., Wu D., Sukreet S., Delaney A., Belfort M.B., Zempleni J