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Experimental model and subject detail Cell lines The human lung adenocarcinoma cell line H838 (gender: male) was purchased from ATCC (CRL-5844) and cultivated in Dulbecco’s modified Eagle’s Medium (DMEM, Lonza) supplemented with 10% fetal calf serum (Gibco), 100 μg/ml streptomycin (Gibco) and 100 U/ml penicillin (Gibco) at 37°C in a humidified atmosphere with 5% CO 2