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As an example, in response to gram-negative LPS, TNF-α induces upregulation of macrophage G6PD expression and activity ( 2.3 Effect of G6PD deficiency on innate immune system function and disease Given the role of G6PD in phagocyte effector function, in the 1960s, it was theorized that G6PD deficiency might impact susceptibility to sepsis and meningitis ( Clinically, there is much interest in understanding the role that G6PD deficiency and an associated aberrant innate immune effector response might play in childhood sepsis

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