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Mechanistic Interface: Aging, Gut Dysbiosis, and Neurodegeneration The gut–brain axis (GBA) is a two-way communication network that connects the central nervous system (CNS) with the enteric nervous system (ENS), immune signals, and microbial metabolites [30,31]

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demonstrated that BDL-rats treated with edaravone, at a dose of 1–10 mg/kg/day intraperitoneally for 14 days, show significant improvements in cholestasis-associated hepatic and renal injury, via reduction of ROS levels, lipid peroxidation, protein carbonylation, and GSSG levels