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Increased resting cerebrovascular tone in individuals along the ADRD progression spectrum (Yew and Nation, 2017) is likely to restrict transient increases in blood pressure into the cerebral circulation

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Such beneficial effects were also obtained with the daily intraperitoneal injections and administration in drinking water (since it is stable in human gastric juice for more than 24 h (reviewed [1,2,3,4,5,6,7,8,9,10,11,12,13,14])), and with μg and ng regimens (reviewed [1,2,3,4,5,6,7,8,9,10,11,12,13,14])