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SARM therapy as an adjuvant to androgen deprivation therapy in prostate cancer may protect against the adverse musculoskeletal, metabolic and neuro-cognitive impacts of hypogonadism induced by GnRH agonists and other therapies for prostate cancer, while at the same time inhibiting prostate cancer tissue proliferation and growth ( To date, there are no convincing clinical data linking hypogonadism with disturbances in growth hormone secretion or responsiveness to stimulation as a potential exacerbating factor in hypogonadism-induced sarcopenia