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The copper is held in a square planar coordination by the alpha-amino group, the deprotonated amide nitrogen, and the imidazole nitrogen of histidine, a geometry that is biologically active at low concentrations

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Lack of SMARCA4 inhibits expression of the aldehyde dehydrogenase ALDH16A1 that binds to the Trx1 active site and inhibits its function but also promotes lysosomal degradation of the redoxin [95]

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