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Approximately 5-10% of patients report mild fatigue or sleep pattern changes at doses above 5 mg, making gradual escalation prudent for first-time users [4]

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RP -derived ASCL1 high cells also readily induced caspase activity upon Cys depletion ( Figure S7A ) and cell death was partially rescued by co-treatment with the pan-caspase inhibitors emricasan or QVD in these cells ( Figure 4C )