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According to researchers from Oregon State University, the amounts of lipoic acid available in dietary supplements (ranging in dosage from 200–600 milligrams) can be as much as 1,000 times greater than the amounts that could be obtained through someone’s diet alone

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One currently recruiting study plans to evaluate 1mg/kg/day leucovorin calcium divided into two daily doses over a 12-week period as compared to placebo in patients between 2.5 and 5 years of age