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Pediatric Implications of Normal Insulin-GH-IGF Axis Physiology - Endotext - NCBI Bookshelf

Children and adolescents may also be diagnosed with localized HSD (L-HSD) or peripheral HSD (P-HSD) if they have joint hypermobility in specific areas rather than throughout the body

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32, 44 We further extend these findings by examining a larger sample of carefully selected tissues for multiple markers of oxidative protein/DNA damage (3-NT, 8-oxo-dG), as well as functional biomarkers of inflammation (3-CT) and mitochondrial superoxide production (aconitase activity)